The use of organic waste as fertilizers in the urban and peri-urban agriculture can contribute to maintain soil fertility and solve food security. This study was done to evaluate the effect of the manure (pig and cattle) on the chemical parameters of the soils in Bobo-Dioulasso area. With that aim in mind, eight (8) farms where the animal waste is used as well as some non-cultivated plots were identified in 2012 for the study. Some samples of soil were taken for chemical analysis in a laboratory. The results showed a fall of the pHH2O balance of 0.46 and 0.51 unit respectively in the 0-10 cm and 10-20 cm depths following the use of the pig waste. The content of the manure had a positive impact on the organic status of the soils by the increase of their C and N rates. An easily absorbed phosphorus rate higher in the 0-10 cm and 10-20 cm depths was noted in the plots which were fertilized with pigs manure. Moreover, the content of the cattle manure is materialized by an increase of total K respectively 1210 ppm for the 0-10 cm depth and 1351 ppm for the 10-20 cm deph. Furthermore, the plots where cattle manure was used had a higher CEC with 7.18meq/100g so be it three (3) times of the plot where the manure was not used. Animal manure could be an alternative to overcome the high cost of the chemical fertilizers.